Palm Kernel Oil in Wound Healing and Dermal Repair: Unveiling the Therapeutic Promise of Elaeis Guineensis Kernel Extracts Through Preclinical Evidence and Ethnopharmacological Insights — A Review

This journal examines the potential of Palm Kernel Oil (PKO) in wound healing and skin repair amidst the high global burden of wounds and limited access to modern therapies, particularly in developing countries. The aim is to synthesize preclinical evidence and ethnopharmacological knowledge related to the effectiveness of PKO. The method used is a narrative literature review of various in vitro, in vivo studies, and traditional practices. The results show that the bioactive components of PKO—such as lauric acid, tocotrienol, phytosterol, and squalene—possess antimicrobial, anti-inflammatory, antioxidant properties, and support tissue regeneration, which significantly accelerate wound closure and improve skin structure in animal models. Traditional evidence also aligns with scientific findings. However, limitations such as the lack of standardization and human clinical trials remain research gaps. From a policy perspective, PKO has the potential to become an affordable, sustainable, and relevant wound care solution for healthcare systems in resource-limited regions.